Primary advanced non-Hodgkin’s lymphoma of bladder with bilateral hydroureteronephrosis: A case report

Aditya Mg,Pratik A,Raisa Ns

doi:10.17727/jmsr.2021/9-27

Abstract

Primary lymphoma of bladder is a very rare entity with a 0.2% incidence of all bladder malignancies. Secondary bladder involvement in malignant lymphoma is more common (10-25%) with preponderance in middle aged females. A non-Hodgkin lymphoma of the bladder can be managed conservatively without surgery and has a better prognosis. Because the presenting symptoms and radiological imaging cannot conclusively rule out a primary bladder lymphoma from other malignant causes, cystoscopy and biopsy with immune-histochemical staining is essential. We present to you a 72-year-old male with complaints of irritative lower urinary tract symptoms and asymptomatic microhematuria. On evaluation computerized tomography (CT) was s/o a large bladder wall mass with bilateral mild hydroureteronephrosis and enlarged pelvic lymphnodes. Cystoscopy and biopsy was done and the report came out to be a non-Hodgkins lymphoma. Whole body positron emission tomography (PET) scan was done which confirmed it to be a primary bladder NHL. Patient was treated with chemotherapy and is now doing well on follow up. We would like to share our experience in managing this case.

Highlights

Bladder malignancies account for almost 3.5 % of the total cancer burden world-wide
Primary lymphoma originating in the urinary bladder is exceedingly rare
A possible explanation is that as there are no germinal follicles or lymphoid tissue developing in the bladder itself, these lymphomas should develop in the background of a preexisting cystitis; 22-40% of the reported cases were preceded by chronic cystitis [3]

Summary

Introduction

Bladder malignancies account for almost 3.5 % of the total cancer burden world-wide. Most of them arise from the epithelium and in general does not have as good a prognosis as one would hope for. *Corresponding Author: Dr Aditya Gupta, 1-c, Sabarmati Industrial Society near Indus Hospital, Sabarmati, Ahmedabad, Gujarat 380005. Received 5 April 2021; Revised 12 June 2021; Accepted 22 June 2021; Published 2 July 2021 In such a scenario, encountering a cancer such as primary bladder non-Hodgkin lymphoma is a sigh of relief.

Results

Conclusion