Abstract
Priapism is a rare but serious side effect seen with many α-adrenergic antagonists, including both typical and atypical antipsychotics.We report here two cases of priapism associated with chlorpromazine. The first one concerns a young man who was admitted for a manic episode in the context of bipolar disorder. The second one was admitted for behaviour disorders. Upon admission, treatment was begun with chlorpromazine. They presented a priapism. The immediate decision was to stop the antipsychotic agents and to adress both patients in the Urologic Surgery department. They were treated with aspiration and irrigation of the corpora cavernosa with intracavernous injection of sympathomimetic drugs followed by a surgical distal cavernoglanular shunt.This study illustrates two cases of priapism associated with chlorpromazine. It is a urologic emergency. This iatrogenic effect of the chlorpromazine is rare but has to be known by the clinicians to prevent the erectile side-effects.
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