Abstract
Selective protection of hydroxyl groups in molecules containing multiple hydroxyl functions is an important reaction in organic synthesis. The protected hydroxyl group is stable under a variety of reaction conditions such as strongly basic media, reactions involving Grignard reagents and lithium alkyls, reduction with hydrides, oxidations, oxidative alkylations, acetylation reactions etc. Therefore there is always a demand for selective reagents for such purposes. This becomes more important when the reagents are available, simple to operate, selective and easy to handle. 3,4-Dihydro-2-H-pyran is one of the most widely used protecting groups in the multi-step organic synthesis and widespread synthetic applications for the protection of hydroxyl functions. A variety of protonic as well as Lewis acid catalysts have been developed for tetrahydropyranylation of hydroxy functions such as acidic Clay, Tos-OH, bis[trimethylsilyl]sulfate, trimethyliodosilane, CuCl2, 7
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