Abstract
With the spread of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to assess the protection conferred by both previous infections and current vaccination. Here we tested the neutralizing activity of infected and/or vaccinated individuals against pseudoviruses expressing the spike of the original SARS-CoV-2 isolate Wuhan-Hu-1 (WH1), the D614G mutant and the B.1.1.7 variant. Our data show that parameters of natural infection (time from infection and nature of the infecting variant) determined cross-neutralization. Uninfected vaccinees showed a small reduction in neutralization against the B.1.1.7 variant compared to both the WH1 strain and the D614G mutant. Interestingly, upon vaccination, previously infected individuals developed more robust neutralizing responses against B.1.1.7, suggesting that vaccines can boost the neutralization breadth conferred by natural infection.
Highlights
In the COVID-19 pandemic, severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) variants started to develop regionally and globally
The highest neutralization (p < 0.0001) was noticed for the D614G mutant, while no significant differences were observed between WH1 and B.1.1.7
D614G neutralization was significantly increased in both vaccinated and infected, vaccinated groups (Figure 4A) as the former group experienced a decay in the neutralizcompared to WH1
Summary
The ma30–50% more transmissible [5] This variant remains susceptible to some jor changes are the mutation N501Y in the receptor-binding domain (RBD); the deletion monoclonal and plasma antibodies from convalescent or vaccinated individuals [6,7,8]. 69–70 which may increase transmissibility [2] and produces a false negative in certain RTHere we analyzed cross-neutralizing plasma antibody titers in individuals infected. The B.1.1.7 variant showed minimal resistance to the is associated with a higher hospitalization risk [3] and higher mortality [4] and several neutralizing capacity from both infected and vaccinated individuals, but its impact was reports indicate that it has a higher secondary attack rate, making this viral variant 30–50%.
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