Previous aneuploidy does not significantly alter 1st trimester free beta hcg and papp-a in subsequent normal pregnancies

Abstract

ObjectiveTo investigate the influence of a previous aneuploid pregnancy on the screening values of a subsequent, normal gestation.Study designWeight and race adjusted free beta hCG and PAPP-A levels were compared in patients with previous aneuploid pregnancy. Data were analyzed using ANOVA of natural log(MOM) values. Significance was determined using Dunnett's procedure for all groups vs. control using a two-sided test at a significance level of 0.05. Dunnett's critical value was adjusted for unequal sample sizes.ResultsThe table shows the geometric mean and SD of natural log(MOM) for free Beta hCG and PAPP-A for each type of previous aneuploidy. The difference between the log(MoM) mean in each group and the “none” group in terms of standard errors was 2.28, 1.81, 2.66, 0.75 for free Beta hCG and 1.87, 2.51, 1.66, 1.82 for PAPP-A, in the previous trisomy 21, trisomy 18, trisomy 13 or 45,X groups, respectively. Dunnett's critical value for 4 groups and 36076 degrees of freedom is 2.61 so only free Beta hCG levels in previous Trisomy 13 were significant.ConclusionTabled 1Free Beta MoMPAPP-A MoMPrevious AneuploidyNGeom Mean (SD)Geom Mean (SD)None33,2260.99 (0.4972)1.00 (0.5675)Trisomy 211,7831.02 (0.5110)1.03 (0.5771)Trisomy 187961.02 (0.5100)1.05 (0.5694)Trisomy 131601.10 (0.5090)1.08 (0.6185)45, X1121.03 (0.4557)1.10 (0.5356) Open table in a new tab ObjectiveTo investigate the influence of a previous aneuploid pregnancy on the screening values of a subsequent, normal gestation. To investigate the influence of a previous aneuploid pregnancy on the screening values of a subsequent, normal gestation. Study designWeight and race adjusted free beta hCG and PAPP-A levels were compared in patients with previous aneuploid pregnancy. Data were analyzed using ANOVA of natural log(MOM) values. Significance was determined using Dunnett's procedure for all groups vs. control using a two-sided test at a significance level of 0.05. Dunnett's critical value was adjusted for unequal sample sizes. Weight and race adjusted free beta hCG and PAPP-A levels were compared in patients with previous aneuploid pregnancy. Data were analyzed using ANOVA of natural log(MOM) values. Significance was determined using Dunnett's procedure for all groups vs. control using a two-sided test at a significance level of 0.05. Dunnett's critical value was adjusted for unequal sample sizes. ResultsThe table shows the geometric mean and SD of natural log(MOM) for free Beta hCG and PAPP-A for each type of previous aneuploidy. The difference between the log(MoM) mean in each group and the “none” group in terms of standard errors was 2.28, 1.81, 2.66, 0.75 for free Beta hCG and 1.87, 2.51, 1.66, 1.82 for PAPP-A, in the previous trisomy 21, trisomy 18, trisomy 13 or 45,X groups, respectively. Dunnett's critical value for 4 groups and 36076 degrees of freedom is 2.61 so only free Beta hCG levels in previous Trisomy 13 were significant. The table shows the geometric mean and SD of natural log(MOM) for free Beta hCG and PAPP-A for each type of previous aneuploidy. The difference between the log(MoM) mean in each group and the “none” group in terms of standard errors was 2.28, 1.81, 2.66, 0.75 for free Beta hCG and 1.87, 2.51, 1.66, 1.82 for PAPP-A, in the previous trisomy 21, trisomy 18, trisomy 13 or 45,X groups, respectively. Dunnett's critical value for 4 groups and 36076 degrees of freedom is 2.61 so only free Beta hCG levels in previous Trisomy 13 were significant. ConclusionTabled 1Free Beta MoMPAPP-A MoMPrevious AneuploidyNGeom Mean (SD)Geom Mean (SD)None33,2260.99 (0.4972)1.00 (0.5675)Trisomy 211,7831.02 (0.5110)1.03 (0.5771)Trisomy 187961.02 (0.5100)1.05 (0.5694)Trisomy 131601.10 (0.5090)1.08 (0.6185)45, X1121.03 (0.4557)1.10 (0.5356) Open table in a new tab