Abstract
Therapeutic role of antioxidant against lipid profile and lipoprotein (choline) was observed by the different researchers, but clinical evidences required about the use of antioxidant vitamins against the lipoproteins. Patients with clinical evidence of cardiovascular disease (CVD) confirmed by standard diagnostic techniques were followed. Newly or recently, diagnosed case subjects were recruited wherever possible. At least 120 cases, subjects both male and female with CVD were selected from a local hospital. Four groups developed on the base of antioxidant therapy and blood samples were collected at zero day, 20 days, 40 days and 60 days. vitamins C and E are the major dietary cellular and lipid antioxidants, respectively; we found no evidence to support the use of vitamin or antioxidant supplements in the reduction of mortality. However, they are helpful in the management of prevention of cardiovascular disease.
Highlights
In clinical setup, various cardiovascular biomarkers such as hs-CRP and NT-ProBNP are commonly executed to assess of the risk of heart failure as well as regulation of cardiovascular pathophysiological processes such as the production of reactive oxygen species (ROS) during the stress processes of necrosis, apoptosis, cell dysfunction, metabolism, and mitochondrial pathways [1]
We evaluated the effect of different treatments like Vitamin C, Vitamin E and outcome of both Vitamin C and E compare with placebo
Antioxidant vitamins lower the blood cholesterol significantly but vitamin E is less effective than vitamin C and composite treatment
Summary
Various cardiovascular biomarkers such as hs-CRP and NT-ProBNP are commonly executed to assess of the risk of heart failure as well as regulation of cardiovascular pathophysiological processes such as the production of reactive oxygen species (ROS) during the stress processes of necrosis, apoptosis, cell dysfunction, metabolism, and mitochondrial pathways [1]. The main source of superoxide radicals is the activity of the NADPH oxidase, which accelerate the oxidation of low-density lipoprotein. Both vitamin C and E in combination reduce the level of the inflammatory biomarkers by decreasing the activity of NADPH oxidase or LDL oxidation. These vitamins promote the production of total cholesterol and HDL level in the body and intensified its effect on reducing the concentration of plasma cardiovascular biomarkers [3]
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