Abstract
A study based on naturally infested cats was designed to evaluate the effectiveness of a single treatment with a topical formulation containing fipronil, (S)-methoprene, eprinomectin and praziquantel, for the prevention of Otodectes cynotis infestation in cats. Six treated cats and six untreated cats were housed with three chronically Otodectes cynotis-infested cats, respectively. The cats of each group were kept together in a 20-m2 room for 1 month. Both clinical examination and ear mite counts were conducted on Day 28. All donor cats were confirmed to be chronically infested with Otodectes cynotis on Day −1 and Day 28. From untreated control cats, 129 live mites were recovered on Day 28 and all cats were found to be infested. In the treated group, three cats were found to be infested, with a total of five live mites recovered, the difference between the two groups being significant (p = 0.003). One treatment corresponded to 96% preventive efficacy at Day 28 based on ear mite counts. With regard to cerumen, the clinical score increased significantly for untreated cats between Day −1 and Day 28 (p = 0.00026) and not for treated cats (p = 0.30). The difference in cerumen abundance was significant between untreated and treated cats on Day 28 (p = 0.0035). Concerning the pruritic reflex in at least one ear, all cats were negative at inclusion. All six untreated cats became positive and showed a reflex on Day 28, whereas no treated cat showed ear pruritus (p = 0.00026).
Highlights
The ear mite, Otodectes cynotis (Hering, 1838), is one of the most common ectoparasites of cats [3, 6]
An experimental model based on naturally infested cats was designed to evaluate the effectiveness of a single treatment with a new topical formulation containing fipronil, (S)-methoprene, eprinomectin and praziquantel (Broadline spot-on, Merial) for the prevention of Otodectes cynotis infestation in cats [12]
A total of 1024 live ear mites were recovered from the donor cats included in the control group 1 and 1415 from the donor cats included in the treated group 2; the difference
Summary
The ear mite, Otodectes cynotis (Hering, 1838), is one of the most common ectoparasites of cats [3, 6]. It is pathogenic in young cats and dogs, and directly transmitted from one animal to another [9, 10]. Several curative treatments are available, mainly including the use of a topical endectocide based on moxidectin or selamectin [1]. What is unknown is the preventive effect that could be obtained regarding direct transmission by infested cats. An experimental model based on naturally infested cats was designed to evaluate the effectiveness of a single treatment with a new topical formulation containing fipronil,. (S)-methoprene, eprinomectin and praziquantel (Broadline spot-on, Merial) for the prevention of Otodectes cynotis infestation in cats [12]
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