Preventive effects of modified chitosan medical anti-adhesion membrane on postoperative intra-abdominal adhesion

Abstract

To explore the preventive effects of modified chitosan medical anti-adhesion membrane on postoperative intra-abdominal adhesion. A total of 86 patients with obstructive colorectal carcinoma undergoing emergent colostomy and second-stage anastomosis were randomly divided into 2 groups (n = 43 each). In the research group modified chitosan medical anti-adhesion membrane were put both at the area of operation and under the incision before abdomen closing, but not so in the control group. The recovery procedures were recorded including gut movement, degree and duration of abdominal pain and cases of adhesive ileus. During the reopening of abdominal cavities 3 to 6 months later, intestinal anastomosis was performed. And adhesive severity was graded blindly and the level of hydroxyproline measured within injured posterior peritoneum and adhesive tissue. As compared with the control, postoperative abdominal pain was weaker; the recovery of gut motor function and eating better ((3.3 ± 1.0) vs (4.2 ± 1.1) days, P < 0.05), the incidence of adhesive ileus lower (1(2.3%) vs 4(9.3%), P < 0.05), adhesion significantly lighter and the hydroxyproline level lower ((0.832 ± 0.071) vs (1.375 ± 0.108) µg/mg protein, P < 0.05) in the research group. Modified chitosan medical anti-adhesion membrane has preventive effects on postoperative intra-abdominal adhesion so as to decrease the incidence of adhesive ileus.