Abstract
Phenanthrene-induced oxidative DNA damage in lymphocyte was evaluated using comet assay and the suppressive effects of Korean medicinal herbs on the DNA damage were examined to screen the medicinal herbs that help to detoxify environmental pollutants. Extracts of Acanthopanax, Benincasae and green tea polyphenols effectively inhibited the phenanthrene-induced oxidative DNA damage in lymphocytes among tested herbs in this study. The present study suggests that Korean medicinal herbs by virtue of their antioxidant potential may be used as effective agents to reduce the oxidative DNA damage by phenanthrene.
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