Abstract
Objective To investigate the preventive effects of curcumin for status epilepticus （SE） induced by lithium chloride-pilocarpine. Methods Totally 45 Sprague-Dawley （SD） rats were randomly divided into three groups： preventive group （ n = 15 ）, non-preventive group （ n = 15 ）, and control group （ n = 15 ）. The latency peroid and incidence of SE were recorded. The surviving neurons were stained by using nissl staining, and the programme death cells were detected by using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling （TUNEL） in hippocampal CA3. Results The SE incidence of preventive group was 66. 7%, which was significantly lower than that of non-preventive group （ P 〈 0. 05 ）. The latency period of preventive group [ （41.0 ± 18. 1 ） min ] was longer than that of nonpreventive group [ （21.5 ±8. 2） min]. The numbers of surviving neurons and programme death cells showed no significant difference between the preventive group and non-preventive group （ P 〉 0. 05）. Conclusion Pretreatment of cureumin can prevent the SE induced by lithium chloride-pilocarpine and the pretreatment can not protect the neuron. Key words: Status epilepticus/chemically induced/drug therapy; Curcumin/pharmacology/therapeutic use; Lithium chloride/ adverse effects; Pilocarpine/adverse effects
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
