Abstract
Deer sinew (DS) has been used traditionally for various illnesses, and the major active constituent is collagen. In this study, we assessed the effects of collagen peptide from DS on bone loss in the ovariectomized rats. Wister female rats were randomly divided into six groups as follows: sham-operated (SHAM), ovariectomized control (OVX), OVX given 1.0 mg/kg/week nylestriol (OVX + N), OVX given 0.4 g/kg/day collagen peptide (OVX + H), OVX given 0.2 g/kg/day collagen peptide (OXV + M), and OVX given 0.1 g/kg/day collagen peptide (OXV + L), respectively. After 13 weeks of treatment, the rats were euthanized, and the effects of collagen peptide on body weight, uterine weight, bone mineral density (BMD), serum biochemical indicators, bone histomorphometry, and bone mechanics were observed. The data showed that BMD and concentration of serum hydroxyproline were significantly increased and the levels of serum calcium, phosphorus, and alkaline phosphatase were decreased. Besides, histomorphometric parameters and mechanical indicators were improved. However, collagen peptide of DS has no effect on estradiol level, body weight, and uterine weight. Therefore, these results suggest that the collagen peptide supplementation may also prevent and treat bone loss.
Highlights
Osteoporosis (OP) is a silent and potentially disabling skeletal disease
The ovariectomized (OVX) rat is a well-known osteoporosis model, because the mechanism of controlling the gain and loss of bone mass is similar to human
Bone mineral density (BMD) is considered to be the standard measure for the diagnosis of osteoporosis and the assessment of fracture risk, which can respond to the bone mass
Summary
Osteoporosis (OP) is a silent and potentially disabling skeletal disease. Postmenopausal women are at greatest risk for developing OP. The hallmark of menopause is a reduction in bone mass caused by an imbalance between bone resorption and formation due to loss of ovarian function [1]. The pathogenesis of postmenopausal osteoporosis involves the interplay of many factors, such as aging, genetic, environmental, hormonal, nutritional, and life style factors [2]. The more widely OP medications include estrogen, calcitonin [3], bisphosphonate [4], calcium [5], vitamin D3, and selective estrogen receptor modulators (SERMs) [6]; some medications of them have serious side effects [7]. The interest to find effective and safe alternatives for the treatment of osteoporosis has grown in recent years
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