Abstract
目的 探讨应用TGF-β1多克隆抗体抑制术后屈指肌腱粘连的效果.方法 将108只来亨鸡随机分成3组,行中趾屈指肌腱切断吻合术,术中分别滴加生理盐水或低、高浓度的TGF-β1多克隆抗体,于术后1、3、8、12周取肌腱进行生物力学测试、苏木精-伊红染色、Masson胶原染色、苦味酸-天狼星红染色、TGF-β1免疫组化染色等.结果 TGF-β1多克隆抗体药物组(5 μg/ml组、10 μg/ml组)肌腱最大延伸率、模拟主动屈曲度要高于对照组,肌腱最大抗拉力在8周时低于对照组,在12周时与对照组无差异;与对照组比较,10μg/ml组炎症过程缩短,塑形过程加速;药物组(5μg/ml组、10μg/ml组)Ⅰ胶原含量减少,Ⅰ/Ⅲ胶原比例下降,TGF-β1的表达降低.结论 TGF-β1多克隆抗体可以有效的抑制TGF-β1在肌腱损伤修复过程中的作用,减少肌腱的粘连,瘢痕组织的形成,而不影响肌腱的强度,这可能是屈肌腱损伤术后粘连潜在的有效方法之一。
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
