Abstract
In this study, mice colitis model was induced by dextran sodium sulfate (DSS), and the preventive effect of Shuidouchi on colitis was observed. The mice were divided into normal group, model group, low-content Shuidouchi feeding group, high-content Shuidouchi feeding group and sulfasalazine group. Serum and colon tissues of mice were detected by endothelin-1 (ET-1), somatostatin (SS), substance P (SP), vasoactive intestinal peptide (VIP), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), interleukin-2 (IL-2), interleukin-10 (IL-10) kits. The results showed that compared with the model group, the feeding of Shuidouchi could significantly increase the length of colon and the ratio of colon weight to colon length in colitis mice (p < 0.05). By feeding Shuidouchi, the serum levels of ET, SP, IL-10 were decreased and SS, VIP, IL-2 were increased in mice with colitis. Detection of colon tissue in mice showed that Shuidouchi could significantly increase the levels of GSH, SOD and decrease the MPO, MDA levels in colitis mice (p < 0.05). It can be seen from this that Shuidouchi has a good preventive effect on colitis.
Highlights
Soybean sauce is a kind of Brewing Seasoning food in southwest China
The results showed that the colon length of model mice was the shortest, and that of normal mice was the longest
vasoactive intestinal peptide (VIP) can inhibit the transcription of iNOS in the body, avoid excessive iNOS transforming into NO in colon tissue, which leads to damage of intestinal mucosa, and control the immune system disorder caused by colitis [15,16,17]
Summary
Soybean sauce is a kind of Brewing Seasoning food in southwest China. It can be eaten directly and used in cooking [1]. Shuidouchi (Fig. 1) is a nutritious soybean product produced by fermentation of soybean. In addition to its delicious taste and simple production, Shuidouchi has many functions including antioxidant effects [3]. In addition to oligosaccharides in soybean raw materials, it contains several new oligosaccharides produced by fermentation of soybean. Soybean oligosaccharides in Shuidouchi can improve digestive function. Shuidouchi can improve the immunity of the body and reduce the toxic substances produced in the intestinal tract, so as to prevent intestinal diseases [5]
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