Abstract
Background: The occurrence of peroneal neuropathy was reported to be higher in cancer patients than in non-cancer patients. Cancer patients should have their nutritional intake carefully managed in order to minimize weight loss and avoid the occurrence of peroneal neuropathy. However, the effect of nutrition support on the prevention of peroneal neuropathy is not understood. Aims: The present study aimed to assess epidemiologically the effect of nutrition support on the occurrence of peroneal neuropathy in cancer patients. Methods: We performed a retrospective case-control study in 178,597 cancer patients admitted to Shizuoka Cancer Center Hospital from 2002 to 2017. The rates of peroneal neuropathy were assessed between the 8-year period before nutrition support started and the 7-year period during which nutrition support performed. Results: Twenty-nine and 14 cases of peroneal neuropathy occurred in the periods without and with nutrition support, respectively. Compared with the period without nutrition support, the risk of peroneal neuropathy decreased by 62% during the period with nutrition support (odds ratio, 0.38; 95% confidence interval, 0.18-0.74; P < 0.05). Conclusion: Our study suggests the preventive effects of nutrition support on peroneal neuropathy in cancer patients.
Highlights
Cancer patients are at a high risk of weight loss, which affects a patient’s response to treatment as well as their survival and quality of life (QOL) [1,2,3]
A total of 66 patients were tentatively diagnosed with peroneal neuropathy from September 2002 to March 2017
Twenty-three cases were excluded for the following reasons: no definite neuropathy or a poor study (n = 7), operation adjacent to the peroneal nerve (n = 5), lumbar radiculopathy (n = 3), history of peroneal neuropathy (n = 3), myotonic dystrophy (n = 2), sciatic neuropathy (n = 1), brain tumor (n = 1), and necrosis of the
Summary
Cancer patients are at a high risk of weight loss, which affects a patient’s response to treatment as well as their survival and quality of life (QOL) [1,2,3]. The importance of providing support to help maintain the nutritional status and QOL has been emphasized in cancer patients [4]. Numerous etiologies have been identified, and the most common cause is compression around the fibular head. The peroneal nerve may be compressed when the adipose tissue around the Peroneal Neuropathy in Cancer Patients fibular head becomes thin due to weight loss [6,7,8]. Cancer patients should have their nutritional intake carefully managed in order to minimize weight loss and avoid the occurrence of peroneal neuropathy. The effect of nutrition support on the prevention of peroneal neuropathy is not understood
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