Abstract
To investigate the preventive effect of genistein on the malignant transformation of oral leukoplakia in hamster cheek pouch. Sixty male Syrian golden hamsters were randomly divided into 4 groups, with two of 20 and two of 10. DMBA solution (0.5% in acetone) was applied topically to the left cheek pouch of male Syrian golden hamsters in group A and B, while animals in group C were painted with acetone, 3 times a week for 6 weeks. For the next 12 weeks, animals in group B received genistein (10 mg.kg(-1).d(-1)) daily by gavage; animals in group A and C received same volume of saline; animals in group D serving as blank control. At the end of the experiment, animals were sacrificed and tissue samples were collected for histopathological examination. No significant differences in the tumor latency and tumor incidence were observed between the control and genistein treated group. No inhibitory effect of genistein on the transformation of oral leukoplakia was observed in hamster.
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