Abstract
The preventive effects of dietary nasunin on a liver injury induced by D-galactosamine (GalN) were investigated in rats. Increases in plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) activities, which were induced by GalN, were suppressed by the feeding of nasunin before the intraperitoneal injection of GalN. Increases in liver oxidized-form glutathione (GSSG) concentration and the ratio of GSSG to reduced-form glutathione (GSH) by the injection of GalN were also suppressed by the dietary nasunin. A slight increase in the liver α-tocopherol concentration and an increase in the liver SOD activity due to the injection of GalN tended to return to the level of the control rat by the feeding of the nasunin. These results suggested that nasunin is effective to prevent liver injury and that it is also effective to prevent oxidative stress which may be induced by GalN-induced liver injury.
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