Abstract
AimsSkin cancer is the most widespread cancer worldwide, mainly caused by exposure to ultraviolet radiation (UV) in sunlight. Utilizing topical preventive agents in routinely daily used cosmetics may prevent UV-related skin damages and skin cancers. γ-Oryzanol (GO) is a natural component derived from rice bran oil, with potential antioxidant and skin anti-aging properties. Main methodsWe biologically thorough studied the antioxidant and anticancer effects of GO in vitro to found the effective signaling pathways, then evaluated the sun protection factor of prepared formulation, and finally investigated the long-term preventive effects of GO-loaded nanoethosomes (GO-NEs) against UVB-induced skin cancer in mice. Key findingsGO-NEs could effectively prevent UVB-induced skin cancer. SignificanceOur results suggest that GO-NEs could be utilized as an innovative ingredient in cosmetics.
Highlights
Cancer is one of the serious human health problems globally, and its treatment is always associated with a variety of challenges 1
The IC50 for GO and GO-NEs according to diphenyl-1272 picrylhydrazyl (DPPH) assay on the first day of preparation were 90.8 and 103, respectively, and for GO-NEs was almost four times lower than free GO after one year (110 and 419.9 μM, respectively.)
The reactive oxygen species (ROS) induction capacity of GO and GO-NEs was studied on B16F10 cells with LC and HC of GO and GO-NEs
Summary
Skin cancer is the most widespread cancer worldwide, mainly caused by exposure to ultraviolet radiation (UV) in sunlight. Utilizing topical preventive agents in routinely daily used cosmetics may prevent UV-related skin damages and skin cancers. Γ-Oryzanol (GO) is a natural component derived from rice bran oil, with potential antioxidant and skin anti-aging properties. We biologically thorough studied the antioxidant and anticancer effects of GO in vitro to found the effective signaling pathways, evaluated the sun protection factor of prepared formulation, and investigated the long-term preventive effects of GO-loaded nanoethosomes (GO28 NEs) against UVB-induced skin cancer in mice. Our results suggest that GO-NEs could effectively prevent UVB-induced skin cancer and could be utilized as an innovative ingredient in cosmetics
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
