Abstract
One hundred and two women with normal renal function having recurrent urinary-tract infections took part in trials of low-dose nitrofurantoin at night to prevent recurrence of infection. In the first trial, 50-100 mg. of nitrofurantoin was used and in the double-blind trial the dose was 50 mg. In the first trial the drug was given for periods up to 5 years and the double-blind trial lasted for up to 1 year. Fifteen of the fifty-two women in the first trial had an abnormal intravenous pyelogram. All the other patients had a normal intravenous pyelogram. Both trials demonstrated that such treatment is highly successful in reducing recurrences of infection, is acceptable to the patients, and almost free from side-effects.
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