Prevention of thromboplastin-induced intravascular coagulation in rabbits by warfarin as monitored by thrombotest.

Abstract

During sustained DIC in rabbits, the protection by warfarin depended on the anticoagulant effect obtained, as reflected by Thrombotest (TT). Moderate treatment (‘IT below 18 %) was sufficient to prevent decrease in thrombocytes and plasma content of various clotting factors, whereas more intense treatment (TT below 9 %) was required to prevent the Occurrence of soluble fibrin in plasma, as indicated by a positive ethanol gelation test. The present observations suggest that, unless the ethanol test becomes negative, anticoagulant treatment must be considered as insufficient.