Abstract
Since the inception of modern chemotherapy one of the chief barriers encountered has been the emergence of drug tolerant bacteria. The discovery and wide use of sulfonamides, various antibiotics and other chemotherapeutic agents, alone or in combination, has not eliminated this potential barrier. In this paper we report the prevention of the development of drug-resistant populations of bacteria from various drug-sensitive strains of Staphylococcus aureus and Aerobacter aerogenes. The emergence of resistant cells was prevented in growth systems containing the polyamines, spermine, or spermidine and any one of the following antibiotics namely, streptomycin, penicillin, erythromycin, and to a lesser extent, tetracycline and chloramphenicol. Only the results with streptomycin and penicillin will be described here.
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