Abstract
Epidemiological surveys recorded that men in the Orient (Japan and China) consuming diets high in soy food were at low risk of developing clinical prostate cancer, compared to a relatively high risk among men in the West who consumed diets low in soy food. Soybeans contain phytoestrogens (isoflavones) with many recorded anticancer mechanisms. The Lobund-Wistar (L-W) rat is a unique model system: approximately 30% develop metastasizing adenocarcinomas spontaneously in the anterior prostate-seminal vesicle complex (P-SV), from which the tumors expand into the dorsolateral lobes. L-W rats are inherently predisposed, possibly by unusually high levels of circulating testosterone (T), to develop P-SV tumors which are T-dependent in the early stages and T-independent in advanced stages of tumorigenesis. L-W rats were fed two diets from age 2-24 months: 1) natural ingredient diet L-485 (Harlan TekLad Diets, Madison, WI) containing soy meal, or 2) a modified starch-casein diet in which soy protein isolate/isoflavones (SPII) replaced casein as a source of protein. At age 24 months, 3 of 99 (3%) rats on diet SPII and 30 of 100 (30%) rats on diet L-485 developed spontaneous P-SV cancers. Rats on the SPII diet manifested a significant reduction of circulating T, approaching physiological levels. Failure of the rats on diet L-485 to prevent P-SV cancer development suggests that soy meal contained a factor(s) that blocked the antiandrogenic action of the phytoestrogen. The spontaneous development of P-SV cancers was significantly prevented in L-W rats consuming the SPII diet from age 2-24 months, possibly through an agonist effect of the soy-derived phytoestrogens.
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