Prevention of progression of cervical carcinogenesis at the stage of postoperative rehabilitation

Abstract

The objective: a study the effect of a complex of hyaluronic acid with plant extracts and a polyphenolic component on cell proliferation and the progression of cervical carcinogenesis.Materials and methods. 74 patients with cervical pathology (average age is 29.8 years) formed the basic group and were examined in the clinic “Doctor Alex” (Kharkiv), 62 women of them had diathermoconization, 12 – laser vaporization of the cervix. Histologically, high-grade squamous intraepithelial lesions (HSIL) was detected in 20 patients, low-grade squamous intraepithelial lesions (LSIL) was found in 46 women, and epidermal endocervicosis – in 8 persons.The patients in the basic group during the postoperative period at the stage of healing additionally used vaginal suppositories of hyaluronic acid with plant extracts and polyphenolic component (aloe vera leaf juice, chamomile flower extract, Centella asiatica extract, sea buckthorn oil, tea tree oil, calendula flower extract, epigallocatechin gallate).The comparison group included 112 women (average age is 32.4 years), 31 of them were diagnosed HSIL, 67 – LSIL, 14 – epidermal endocervicosis; laser vaporization was performed in 21 women, diathermoconization – 91. These patients received antiviral therapy. Markers of proliferation p16 and Ki-67 and the presence of human papilloma virus (HPV) were determined in all women of both groups.Results. 6 months after the treatment, there was a decrease in the frequency of HPV in the basic group (from 55.4% to 5.4%) and in the comparison group (from 51.8% to 6.3%), proliferation markers – from 23.0% to 2.7% and from 20.5% to 6.3%, respectively. In the basic group, a more rapid epithelialization of the cervix was established, which after laser vaporization lasted 28.7 days, after diathermoconization – 36.9 days, and in the comparison group these indicators were, respectively, 30.2 and 44.6 days.Conclusions. The use of laser vaporization or diathermoconization of the cervix in the patients with background cervical pathology, LSIL and HSIL in combination with courses of vaginal suppositories containing hyaluronic acid with plant extracts and a polyphenolic component, can significantly reduce the incidence of HPV, leads to a faster recovery of its epithelium and can be comparable in the effectiveness to the combination of laser vaporization / diathermoconization with antiviral therapy.