Prevention of postoperative pancreatic fistula for pancreaticoduodenactomy in our hospital

Abstract

The kinetics of the irreversible and reversible binding of sulphur(IV) oxospecies (S(IV)) in the system: glucose-glycine-S(IV) are reported at pH 5·5 and 55°C. The formation of 3-deoxyhexosulose (DH), a reaction intermediate, is of first order with respect to glucose and glycine, but is also catalysed by S(IV) according to: DH is subsequently converted to 3,4-dideoxy-4-sulphohexosulose (DSH) in a process which is independent of [S(IV)]. In a system containing [glucose] = 1·0m, [glycine] = 0·5m and [S(IV)] = 0·01–0·10m, reversible binding of S(IV) is a result of the formation of hydroxysulphonates of glucose and DSH. No evidence could be found for the formation of the hydroxysulphonate of DH which had been previously demonstrated to play a role in the reaction between DH and S(IV) when studied in isolation. The effect of pH on the rate of loss of total S(IV) is also reported.Suggestions as to the mechanism of the involvement of S(IV) in the formation of DH are made and reasons for the non-formation of the hydroxysulphonate of DH are considered.