Abstract
Alfacalcidol has been found to be effective in the prevention of postmenopausal osteoporosis and corticoid-induced osteoporosis. Bone loss in rheumatoid arthritis (chronic polyarthritis) can also be effectively stopped, and initial results have shown that the fracture rate can also be reduced for these patients. It is highly interesting that alfacalcidol is more effective in reducing bone loss in patients after heart transplantation and permanent application of immunosuppressives than biphosphonates. It is remarkable that recent animal experiment studies have proven that alfacalcidol improves the mechanical stability of the bone.
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