Abstract
Phytate-removed and deamidated soybean β-conglycinin (PrDS) prepared by ion-exchange resins was supplemented to be 4% in the diet administered to ovariectomized rats to investigate its preventive effect on osteoporosis. The apparent calcium absorption rate decreased following ovariectomy and was not replenished by oral administration of phytate-removed soybean β-conglycinin (PrS) or casein. On the other hand, administration of PrDS restored the calcium absorption rate to the same level as the sham group. Markers of bone resorption, such as serum parathyroid hormone (PTH) and urinary deoxypyridinoline (DPD), increased, and the bone mineral density and breaking stress decreased following ovariectomy. However, PrDS supplementation suppressed the changes caused by the decrease in calcium absorption from the small intestine. Therefore, PrDS supplementation shows promise for the prevention of postmenopausal osteoporosis.
Highlights
Bone is a supporting tissue that maintains its structural integrity and morphology through repetitive resorption and formation
After one week of feeding of each experimental diet, the calcium absorption rate was reduced in the ovariectomized groups, but a similar reduction was not observed in the group fed Phytate-removed and deamidated soybean β-conglycinin (PrDS)
Numerous studies have reported that estrogen deficiency brought on by ovariectomy causes a reduction in intestinal calcium absorption [16,17,18,19]
Summary
Bone is a supporting tissue that maintains its structural integrity and morphology through repetitive resorption and formation It acts as a calcium reservoir in the human body and helps to regulate the serum calcium level [1]. A lowered estrogen level enhances bone resorption, which causes calcium loss in bones, whereas a lowered vitamin D level reduces the biosynthesis of calcium-binding protein and suppresses calcium absorption in the small intestine. In both cases, adequate calcium intake is essential to prevent osteoporosis
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