Abstract
Rhesus monkey infants were injected subcutaneously at birth with 12 to 100 mumol of tin-protoporphyrin IX, a competitive inhibitor of microsomal heme oxygenase. The elevated unconjugated serum bilirubin levels of the neonates receiving this metalloporphyrin rapidly declined to near adult levels by 24-30 h. Control neonates which received an injection of saline exhibited normal physiologic hyperbilirubinemias of from 3-6 mg/dl by 12-24 h as expected. These studies establish the effectiveness of tin-protoporphyrin IX in depressing bilirubin production and preventing physiologic hyperbilirubinemia in simian neonates. Two of six animals receiving the metalloporphyrin exhibited signs of toxicity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
