Prevention of meningococcal meningitis

Abstract

In Germany, the incidence of meningococcal disease is approximately 1/100,000 and has not risen during recent years. Transmission occurs by direct contact with respiratory droplets, mostly from asymptomatic carriers and less frequently from patients with meningococal disease. The incubation period can vary from 2-10 days but usually is 3-4 days. Incidence is highest in children and decreases with age. The mortality from meningococcal disease is approximately 10%. In case meningococcal meningitis is clinically suspected antibiotic treatment (in Germany with penicillin G or a cephalosporin) should not be delayed. Patients must be isolated for at least 24 hours after the institution of antibiotic therapy. For early detection of local outbreaks, public health authorities should be quickly informed of suspected cases. Persons in close contact should be treated with antimicrobial chemoprophylaxis. In addition to rifampin, ciprofloxacin or ceftriaxone can be used for chemoprophylaxis. For control of local outbreaks of serogroup C meningococcal disease, the meningococcal vaccine can be used.