Abstract
Agents known to increase intracellular levels of cyclic 3′5′-adenosine monophosphate (cyclic AMP) in a variety of tissues were examined for their affect on macrophage tumoricidal activity in vitro. Cholera toxin and prostaglandin E 1 and E 2 consistently inhibit the cytotoxicity of interferon-treated macrophages for MBL-2 lymphoblastic leukemia cells. These observations suggest a role for cyclic AMP in modulating macrophage functional activity. The finding that dibutyryl cyclic AMP inhibits tumor cell killing by interferon-activated macrophages further supports this view.
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