Abstract
Acute myocardial ischemia (MI) in anaesthetized cats as induced by ligation of the left anterior descending coronary artery is followed by a rapid decrease in circulating platelet count. This decrease occurs within the first 20 min after MI and amounts to 30–35% of the initial value prior to coronary artery ligation: 499+32 × 103 platelets/μl = 100% (n = 20). There is no reduction of the circulating platelets in sham-operated cats while a modest further decrease in platelet count in MI-cats occurs during post-MI observation period. Treatment of the cats with prostacyclin (PGI2)(0.5 nmoles/ kg × min) starting 30 min after MI, increased the diminished platelet count to that of sham-operated controls within 30 min. PGI2 also prevented the loss of myocardial cathepsin D- and creatine phosphokinase-activities in the infarcted area and inhibited the ST-segment elevation. It is concluded that (I) pronounced and persistent decrease in circulating platelet count, probably by formation of platelet aggregates, is an important phenomenon accompanying acute MI in cats, (II) agents like PGI2 that inhibit platelet aggregation and are capable of producing dispersion of circulating platelet aggregates might exert their beneficial cardiac effects during myocardial ischemia by an action on blood platelets.
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