Abstract
Background: Hypertension and tachycardia-induced after laryngoscopy and intubation can be prevented by various methods like deep inhalation anesthesia, intravenous opioids, topical intravenous lidocaine, intravenous adrenergic blocking drugs, and pretreatment with antihypertensive.Methods: It is a randomized controlled double-blind prospective study of two groups consisting of 30 patients in each group. Group A was the control group and group B were Nifedipine group who were pretreated with Nifedipine. This study aimed to assess the effectiveness of pretreatment with nifedipine in the prevention of the hypertensive response to laryngoscopy and endotracheal intubation in normotensive patients undergoing elective surgery.Result: Sublingual nifedipine was significantly effective in decreasing systolic and diastolic blood pressure produced by laryngoscopy and tracheal intubation, but its role in decreasing pulse rate was not significant. Conclusion: Nifedipine is useful to prevent laryngoscopy and intubation induced hemodynamic response.
Highlights
Transient hypertension and tachycardia are commonly associated with laryngoscopy and tracheal intubation.[1,2] These must be considered as potent noxious stimuli because of their effects on autonomic nervous activity
Result: Sublingual nifedipine was significantly effective in decreasing systolic and diastolic blood pressure produced by laryngoscopy and tracheal intubation, but its role in decreasing pulse rate was not significant
Systolic blood pressure increased after laryngoscopy and intubation in control patients as well as in nifedipine treated patients, the increase in systolic blood pressure was significantly less in nifedipine treated patients (p
Summary
Transient hypertension and tachycardia are commonly associated with laryngoscopy and tracheal intubation.[1,2] These must be considered as potent noxious stimuli because of their effects on autonomic nervous activity. Hypertension and tachycardia may be inconsequential in healthy patients but detrimental to those with ischaemic heart disease or increased intracranial pressure and have been the subject of many studies to determine an effective method of prevention. Various attempts have been made to block this stress response but most of the attempts are only partially successful.[3,4]. Hypertension and tachycardia-induced after laryngoscopy and intubation can be prevented by various methods like deep inhalation anesthesia, intravenous opioids, topical intravenous lidocaine, intravenous adrenergic blocking drugs and pretreatment with antihypertensive
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