Prevention of Epinephrine-induced Arrhythmias with Lidocaine during Thiopental and Methoxyflurane Anesthesia in Sheep

Abstract

Edjtehadi, M. and Mehrabani, D. 2005. Prevention of epinephrine-induced arrhythmias with lidocaine during thiopental and methoxy flurane anesthesia in sheep. J Appl. Anim. Res., 27: 55–59. The present experiment was designed to evaluate efficacy of lidocaine for prevention of epinephrine induced arrhythmias in sheep. The results indicated that lidocaine alone could prevent these arrhythmias in non-anesthetized and thiopental and methoxyflurane anesthetized animals. The results from electrocardiogram parameters indicated hat lidocaine could not prevent the decrease in P wave, PR, QT, ST intervals and, an increase in T amplitude induced with epinephrine in such animals. Nevertheless, T amplitude in all groups increased significantly more than control value. In conclusion, we suggest that lidocaine could be safely used clinically to prevent the lethal arrhythmias, due to catecholamine-anesthetic interaction, in non-anesthetized and thiopental and methoxyflurane anesthetized animals.