Abstract
This study utilizes oral 250HD3 in an attempt to prevent early neonatal hypocalcemia in newborn rats and humans. Pregnant rats were fed a normal diet or one deficient only in vitamin D. Pups were divided into those litters treated with 250HD3 orally, 0.5μg/d, for the first five days of life, and those given sodium chloride as controls. Neonatal rat sera were obtained on the sixth day of life with samples from a single litter pooled for analysis. Data are expressed as mean ± S.E.M.: The significant decrease in serum levels of ionized calcium, magnesium and 250HD in the offspring of vitamin D deficient rats was corrected by treatment. Preliminary experience in human premature neonates treated for the first five days of life with oral 250HD3, 2μg/kg/d, revealed comparable data. Serum levels of ionized calcium increased over this period and urinary calcium: creatinine ratios remained low (< 0.1). These data indicate:1-oral 250HD3 is well absorbed; 2-oral 250HD3 in this dose does not cause hypercalcemia or hypercalciuria; and 3-most significantly, oral 250HD3 may prevent early hypocalcemia.
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