Abstract
The aim of the present study was to determine whether orally applied collagen fragments (CFs) could affect the development of obesity in obese rats. To this end, experimental rats that were exposed to a high-calorie diet (HCD) for four weeks were randomly divided into two groups: HCD and HCD+CFs, with both groups continuing to receive the HCD. However, rats from the HCD+CFs group were also provided with CFs in a 0.05-M citrate buffer (pH 5.0) (1 g·kg -1 of body weight) by intragastric administration, every other day for the next six weeks. Selected parameters associated with obesity development and insulin resistance, as well as serum markers of oxidative stress and the cytokine profile were assessed at the end of the 10 th week. Supplementation with CFs resulted in a decrease in body weight and body mass index when compared to animals exposed to a HCD. The observed changes were assumed to be caused by a lower food intake and increased water intake by obese rats treated with CFs. Enhanced activity of superoxide dismutase (SOD), catalase (CAT) and decreased malondialdehyde (MDA) concentration were detected in the HCD+CF group of animals when compared to untreated HCD-fed rats. Administration of CFs also lowered the serum concentrations of the proinflammatory cytokines IL-1β and IL-12, whereas the concentration of the anti-inflammatory cytokine IL-10 was significantly increased and the concentration of cytokine IL-4 was near the control value. Decreased concentrations of fasting blood glucose, glycated hemoglobin (GHbA1c) and serum insulin and increased tolerance to glucose in the oral glucose tolerance test (OGTT) were observed in the HCD+CF group of animals when compared to rats in the HCD group. We concluded that CFs mediated a therapeutic effect on obesity development in rats exposed to a HCD by affecting pathways involved in obesity pathogenesis. https://doi.org/10.2298/ABS170401027R Received: April 1, 2017; Revised: June 1, 2017; Accepted: June 13, 2017; Published online: August 1, 2017 How to cite this article: Raksha NG, Potalitsyn PY, Yurchenko AV, Halenova TI, Savchuk OM, Ostapchenko LI. Prevention of diet-induced obesity in rats by oral application of collagen fragments. Arch Biol Sci. 2018;70(1):77-86.
Highlights
Obesity is a medical condition with a multifactorial origin and it is recognized as one of the leading health care problems [1]
Numerous peptides from various sources have been reported to have anti-obesity effects by modulating the pathways involved in obesity pathogenesis
Antiobesity activities were found in whey, soy and casein protein hydrolysates [24]
Summary
Obesity is a medical condition with a multifactorial origin and it is recognized as one of the leading health care problems [1]. The incidence of obesity has sharply increased due to rapid socio-economic development and dramatic lifestyle changes. Obesity is a high-risk factor for the development of many metabolic complications, including cardiovascular disease, insulin resistance, type II diabetes, certain forms of cancer and sleep-breathing disorder [2,3]. Despite the many efforts directed at the prevention and treatment of obesity and obesity-related metabolic dysfunction, there is no universally satisfactory treatment. Many drugs are available for the treatment of obesity, but most of them become less effective with time or have adverse side effects.
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