Abstract
Photodynamic therapy using hematoporphyrin derivative (Hpd), or its semipurified form, dihematoporphyrin ether (DHE), in combination with light, has proven effective in the treatment of several types of neoplasms including squamous cell carcinoma. A major disadvantage of this therapy is the long-term retention of these drugs in skin, which may result in cutaneous phototoxicity for weeks after treatment. Singlet oxygen has been identified as the primary cytotoxic product in the reaction of Hpd and light in vitro. This study demonstrates the protective effect in vivo of the singlet oxygen scavengers 1,3 diphenylisobenzofuran and l-tryptophan on the skin of young rats exposed to light after receiving DHE.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: American Journal of Otolaryngology--Head and Neck Medicine and Surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.