Abstract
Dragstedt, Van Prohaska and Harms1 reported observations on a substance present in pancreas which permits survival and prevents liver changes in depancreatized dogs. To this substance they gave the name “Lipocaic”. The interesting effects of this substance on lipoid metabolism led us to investigate its effect on the atherosclerosis which can be produced in rabbits by feeding cholesterol and foods high in cholesterol content. This experimental vascular change in rabbits has been studied particularly by Anitschkow,2 Bailey,3 Clark-son,4 Dominguez,5 and Duff.6 Lipocaic was prepared according to the method of Dragstedt, Van Prohaska and Harms.1 The procedure involves the extraction of fresh pancreas with 60% ethyl alcohol. The alcohol extract is then evaporated at a temperature less than 40°C. The residue is extracted with sulphuric ether. The fat-free extract dissolved in water was so diluted that 5 cc. contained the extract of 50 gm. of pancreas.In this study, the diet fed to all the rabbits consisted of a ...
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