Abstract
Objective To evaluate the prevention effect of mesenchymal stem cells from umbilical cord treatment on acute graft-versus-host disease (GVHD) after haplo-identical hematopoietic stem cell transplantation. Methods Eighteen serum sample was collected from patients who received haplo-identical hematopoietic stem cell transplantation at different points after transplants, the levels of tumor necrosis factor-α, interleukin-6, interferon-γ were detected by ELISA, the incidence of acute GVHD was recorded. Results Four cases of acute GVHD was recorded among in 18 patients, two cases was in degree Ⅱand two cases was in degree Ⅲ-Ⅳ with acute GVHD, the total incidence of acute GVHD was 22.2% and serious GVHD was 11.1%. Compared with patients without acute GVHD, the level of three cytokines in the patients with acute GVHD was increased. Conclusions Mesenchymal stem cells treatment can reduce the incidence and severity of acute GVHD of the patients received haplo-identical hematopoietic stem cell transplantation, the mechanism of mesenchymal stem cells treatments may be related to inhibition of cytokines in serum. Key words: Mesenchymal stem sells; Haplo-identical hematopoietic stem cell transplantation; Graft-versus-host disease; Cytokines
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
