Abstract
Addiction to opiates such as morphine is one of the major public health problems. Some reports show that Matricaria chamomilla extract contains flavonoids, which exert Benzodiazepine-like activity and inhibited the expression of abstinence syndrome in morphine-dependent animals. Objective: To determined and comparison the effect of Matricaria chamomilla extract injection on morphine withdrawal syndrome signs (MWS) in rats. Methods: 30 male rats (200-300gr) (n=6) were tested in 2 groups: control and morphine groups ( twice daily for 7 days) and divided in 4 sub groups: saline group which was received only saline and Mc group were received Mc extract (10, 20, 50mg/kg I.P) in day 7, 30 min before naloxan administration. In the end of training day all groups were received naloxane (5mg/kg I.P) 3hour after last injection of morphine and then the frequencies of withdrawal behavior were assessed for 30min.Finding: Our results show that I.P administration of MC extract dose dependently attenuates most of morphine withdrawal syndrome. Conclusion: These result suggested that injection of MC extract in to the I.P is helpful for morphine withdrawal syndrome treatment.
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