Prevention and Treatment of Alzheimer's Disease Through CRISPR/Cas Technology

Abstract

Neuronal loss and the stereotyped deposition of misfolded proteins are hallmarks of Alzheimer's disease (AD), A neurodegenerative disease related to age that is common, progressive, and fatal. The formation of amyloid β oligomers may contribute to the pathogenesis of multiple diseases, including the development of tau neurofibrillary tangles and oxidative stress. Between 20% and 40% of persons with AD go on to have severe dementia or pass away within three years. The only things that the current generation of Alzheimer's medications can do are postpone the onset of the illness and make a maximal difference in the lives of those who use them.Early diagnosis, management, and treatment of individuals with neurodegenerative disorders are crucial .But there are currently no relevant treatment options for the accumulation of amyloid beta and neurofibrillary tangles. CRISPR has been widely used in molecular biology research because it is fast, effective, cheap, and easy to operate compared to traditional gene editing methods, and thus has quickly become one of the most popular biological research tools. This article intends to use the gene editing CRISPR technology, which has the advantages of simple design, time period, and low cost, to knock out or edit the genes corresponding to Alzheimer's disease to achieve targeted treatment of this accumulation phenomenon.