Prevention and treatment of acute renal failure: An experimental study

Abstract

1. 1. Experimental renal failure has been produced in seventy-six dogs by a combination of operation (right nephrectomy), ischemia, and the administration of acid hematin solution. Mannitol, low molecular weight dextran, THAM, and 5 per cent dextrose in water have been compared regarding their relative effectiveness in preventing or prolonging survival after the induction of renal failure. 2. 2. Mannitol, low molecular weight dextran, and the organic buffer THAM, in the experimental setting of this study, did not appear to be more beneficial than 5 per cent dextrose in water in preventing or prolonging survival after the induction of acute renal failure. Extensive petechial hemorrhages involving the mesentery and serosa of the bowel were frequently observed in animals receiving low molecular weight dextran. 3. 3. Control groups (animals receiving 5 per cent dextrose in water solution) consistently had the most seven day survivors as well as the longest mean survival times of any of the groups studied. 4. 4. The beneficial effect of adequate hydration prior to the performance of diagnostic procedures or operations known to be associated with renal damage is emphasized.