Abstract
It has been known that diabetes mellitus is known to have a high risk of cardiovascular diseases as well as osteoporosis. Prevention and treatment of vascular calcification in patients with diabeties mellitus by anti-osteoporosis agents is prospected bcause similar molecular mechanisms in bone tissue were found in calcified lesion in blood vessels. However, the anti-vascular calcification effect has not always been observed in clinical practice in contrast to basic research and animal experiments. More optimized clinical research desined for prevention of vascular calcification as primary outcome, such as applying elaborated method for detemination of calcified lesion, is needed.
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