Prevention and treatment effect of baxianxiaoyao decoction medicated bathing on rat pressure injury

Abstract

Objective To study the preventive and therapeutic effects of Baxianxiaoyao decoction medicated bath on pressure injury wound in rats. Methods The research was started from April 2016 to February 2017. The experiment was approved by the animal experimental ethics committee and was finished in the basic medical laboratory of Nagano University of Nursing in Japan. A total of 24 rats were divided into 3 groups averagely, and there were the control group (group A) , the tap-water bath group (group B) and the traditional Chinese medicine bath group (group C) . Group B rats used tap-water bath, and group C rats used traditional Chinese medicine bath, while the rats in group A did not bath. After bathing for 2 weeks, the pressure injury model was made on the rats' skin, and then the average of ulcer area and the maximum - minimum concentration difference were calculated by Image-J ; besides the healing rate, wound center temperature, skin moisture were compared among the three groups. Results For the 12 h pressure injury area after three groups rats model established, the group A was (137.060±18.258) mm2, Group B (123.310±14.969) mm2, group C (92.520±11.159) mm2 (F=73.235, P 0.05). Conclusions Baxianxiaoyao Decoction medicated bath is an effective way to prevent and treat pressure injury wound, and it can promote wound healing. Key words: Drugs, Chinese herbal; Rats; Pressure injury; Baths therapy; Baxianxiaoyao decoction