Abstract
Alpelisib is a modern targeted drug for the treatment of patients with hormone receptor-positive HER2-negative metastatic breast cancer with a PIK3CA gene mutation. Blockade of PI3K can significantly increase progression-free survival, however, it is accompanied by adverse events, the most common of which is hyperglycemia. The article presents recommendations for risk estimation, prevention and correction of alpelisibinduced hyperglycemia.
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