Preventing Spinal Hypotension During Cesarean Birth With 2 Initial Boluses of Norepinephrine in Chinese Parturients: A Randomized, Double-blind, Controlled Trial

Abstract

(Anesth Analg. 2023;136:94–100) Spinal hypotension is a common adverse outcome during cesarean delivery and impacts 70% to 80% of mothers. Norepinephrine has proven effective in preventing spinal hypotension, however, the optimal regimen of norepinephrine has yet to be determined. This study hypothesized an initial norepinephrine bolus helps prevent spinal hypotension compared with continuous norepinephrine alone. The aim of this study was to compare 2 loading boluses of norepinephrine (0.05 and 0.10 μg/kg) followed by regular 0.05 μg/kg/min infusion during cesarean delivery in ability to prevent spinal hypotension using noninvasive blood pressure measurements.