Abstract
Salvia miltiorrhiza Radix root extracts(SMR) was evaluate for inhibition of the progress of bone loss induced by ovariectomy(OVX) in rats. We measured body weight and bone histomorphometry in sham, OVX and SMR-administered OVX rats. From light microscopic analyses, porous or erosive appearances were observed on the surface of trabecular bone of tibia in OVX rats, whereas those of the same bone in sham rats and in SMR-administered OVX rats were composed of fine particles. The trabecular bone area and trabecular thicjness in OVX rats were decreased by 50% from those in sham rats, and these decreased were completely inhibited by administration of SMR for 7 weeks. In this study, the mechanical strength in femur neck was significantly enhanced by the treatment of SMR for 7 weeks. In OVX rats, free T3 was normal in all cases, whereas free T4 was significantly increased. Although there was no difference between OVX and SMR-administered ratn in T3 levels, we have found significant difference between them in T4 level. These results strongly suggest that SMR may be benifical for preverting bone loss in OVX rats.
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