Abstract

Objectives: Low and Middle-Income Countries are experiencing a fast-paced epidemiological rise in clusters of non-communicable diseases such as diabetes and cardiovascular disease, forming an imminent rise in multimorbidity. However, preventing multimorbidity has received little attention in LMICs, especially in Sub-Saharan African Countries. Methods: Narrative review which scoped the most recent evidence in LMICs about multimorbidity determinants and appropriated them for potential multimorbidity prevention strategies. Results: MMD in LMICs is affected by several determinants including increased age, female sex, environment, lower socio-economic status, obesity, and lifestyle behaviours, especially poor nutrition, and physical inactivity. Multimorbidity public health interventions in LMICs, especially in Sub-Saharan Africa are currently impeded by local and regional economic disparity, underdeveloped healthcare systems, and concurrent prevalence of communicable and non-communicable diseases. However, lifestyle interventions that are targeted towards preventing highly prevalent multimorbidity clusters, especially hypertension, diabetes, and cardiovascular disease, can provide early prevention of multimorbidity, especially within Sub-Saharan African countries with emerging economies and socio-economic disparity. Conclusion: Future public health initiatives should consider targeted lifestyle interventions and appropriate policies and guidelines in preventing multimorbidity in LMICs.

Highlights

  • Global mortality among adults is primarily caused by non-communicable diseases (NCDs) of cardiovascular disease (CVD), cancer, respiratory disease, and diabetes, with related annual mortality records showing 17.9, 9, 3.9 and 1.6 million respectively for each disease [1]

  • Future interventions in Sub-Saharan Africa could address a cluster of emerging NCDs forming multimorbidity through lifestyle interventions, especially when such approaches are personalised towards local needs. This narrative review summarises key epidemiological multimorbidity determinants and highlights specific public health challenges related to multimorbidity prevention strategies, especially through lifestyle in low and middle-income countries (LMICs) placing emphasis on Sub-Saharan Africa, and its future regionally-relevant health policies. This narrative review focused on preventing MMD through mapping its determinants with potential lifestyle prevention approaches in Sub-Saharan African LMICs

  • Perhaps multicomponent lifestyle interventions targeted towards highly prevalent multimorbidity clusters, especially hypertension, diabetes and cardiovascular disease could provide an early effective prevention of multimorbidity in LMICs, especially within Sub-Saharan African countries with emerging socio-economic disparity

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Summary

Introduction

Global mortality among adults is primarily caused by non-communicable diseases (NCDs) of cardiovascular disease (CVD), cancer, respiratory disease, and diabetes, with related annual mortality records showing 17.9, 9, 3.9 and 1.6 million respectively for each disease [1]. These NCDs are known to be preventable through addressing their modifiable risk factors. Of those figures, 85% (15 million) NCDs-related mortalities are in low and middle-income countries (LMICs) [1]. The recent epidemiological transition from CDs to multiple NCDs in Sub-Saharan

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