Abstract
Probiotics are ingested live microbes that can modify intestinal microbial populations in a way that benefits the host. The interest in probiotic preventative/therapeutic potential in allergic diseases stemmed from the fact that probiotics have been shown to improve intestinal dysbiosis and permeability and to reduce inflammatory cytokines in human and murine experimental models. Enhanced presence of probiotic bacteria in the intestinal microbiota is found to correlate with protection against allergy. Therefore, many studies have been recently designed to examine the efficacy of probiotics, but the literature on the allergic skin disorders is still very scarce. Here, our objective is to summarize and evaluate the available knowledge from randomized or nonrandomized controlled trials of probiotic use in allergic skin conditions. Clinical improvement especially in IgE-sensitized eczema and experimental models such as atopic dermatitis-like lesions (trinitrochlorobenzene and picryl chloride sensitizations) and allergic contact dermatitis (dinitrofluorobenzene sensitization) has been reported. Although there is a very promising evidence to recommend the addition of probiotics into foods, probiotics do not have a proven role in the prevention or the therapy of allergic skin disorders. Thus, being aware of possible measures, such as probiotics use, to prevent/heal atopic diseases is essential for the practicing allergy specialist.
Highlights
The interest in probiotic preventative/therapeutic potential in allergic disorders stemmed from the fact that probiotics have been shown to improve intestinal dysbiosis and permeability and to reduce inflammatory cytokines
Such effects would be desirable in treating allergic disorders including atopic dermatitis (AD)
These results have been lately questioned by other trials, which reported no difference in the development and therapy of AD in neonates supplemented with LGG or other probiotics
Summary
The interest in probiotic preventative/therapeutic potential in allergic disorders stemmed from the fact that probiotics have been shown to improve intestinal dysbiosis and permeability and to reduce inflammatory cytokines. Of probiotic use in skin allergy reactions, including their preventative/therapeutic role in AD. These studies strongly suggest that the pattern of colonization in the first weeks of life may influence the patterns of allergic disease development [7, 8] These notions have been supported by observations that gut flora can influence local and systemic immune responses. There have been only several studies to address the role of probiotics in primary prevention of allergic skin conditions, with a reported suspicious reduction in the incidence of eczema. Since the role of probiotics in allergy prevention has remained controversial and there has been an urgent call for similar studies to address this further, this paper will try to highlight the role of probiotics in the therapy/prevention of allergic skin reactions and the future of this therapy
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
