Abstract
Investigators from the Vascular Effects of Infection in Pediatric Stroke (VIPS) group studied the risk of arterial ischemic stroke (AIS) associated with minor infection and routine childhood vaccinations.
Highlights
This paper builds on previous retrospective cohort studies supporting a relationship between infection and AIS [2,3] in particular for arteriopathy [4]
There are many proposed mechanisms by which recent infection could increase the risk of AIS: by inflammation causing a prothrombotic state, direct arterial wall infection and inflammation, or dehydration
The juxtaposition of recent infection increasing the risk of AIS while more comprehensive vaccination reducing this risk, is striking
Summary
This paper builds on previous retrospective cohort studies supporting a relationship between infection and AIS [2,3] in particular for arteriopathy [4]. There are many proposed mechanisms by which recent infection could increase the risk of AIS: by inflammation causing a prothrombotic state, direct arterial wall infection and inflammation, or dehydration.
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