Abstract
In December 2019, in the province of Hubei (Wuhan-China), there was an outbreak of a coronavirus-associated pneumonia, called coronavirus disease 2019 (COVID 19).(1) SARS-CoV-2 enters the cell by angiotensin-converting enzyme 2 (ECA 2) receptors that are expressed in multiple organs, including testicular tissue.(2) Protein S is most likely primed by transmembrane serine protease 2 (TMPRSS2), which interacts with ACE receptors, resulting in the successful entry of the virus into the cell.
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