Prevalencia de marcadores serológicos para hepatitis B y delta e infección intrafamiliar en el valle del río Pampas, Perú¹

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Objective: To determine the prevalence of serum markers in infection by B (HBV) and Delta (HDV) hepatitis virus in school population of the Pampas River valley, and to assess the risk for familial transmission of HBV. Materials and methods: This research was carried out in eight sites in Pampas River valley (Ayacucho-Andahuaylas) between March and November 2000, and it had two phases: In the first phase (prevalence), we selected a randomly stratified sample comprising 130 subjects from the total school population. The subjects were assessed in order to determine the presence of HBsAg, anti- HBcAg and anti-HDV antibodies (the latter test was performed only in the subjects found to be positive for HBsAg). In the second phase (familial transmission), we performed a case-control study. The cases were families of the HBsAg reactive students and controls were families of non-HBsAg reactive students (1/1 relation). In all of them, we determined the presence of anti-HBcAg, HBsAg, and HbeAg. Results: 18 (13,8%) students were found to be HBsAg carriers, 93 (71,5%) had anti-HBcAg antibodies and 3 (16,7%) of the 18 HBsAg carriers had anti-HDV antibodies. There were no significant differences for the prevalence of serologic markers for HBV between cases and controls. Conclusions: The sites at Pam- pas River valley (Ayacucho-Andahuaylas), have high endemicity for HBV and intermediate endemicity for HDV. No risk for familial transmission was found.