PREVALENCES OF HELICOBACTER PYLORI AMONG NSAID USERS AND NON USERS

Abstract

Background:The main etiology of gastroduodenal ulcer are NSAID and Hp. The role if Hp infection to the patients who use NSAID is still controversy. We compare the prevalence of Hp infection among ulcer and non ulcer patients in those who used NSAID and who didn’t use.Material & Methods:A retrospective study had been done from 1995 ‐ 1988 to 248 patients who were proven to have ulcer and non ulcer by endoscopic examination. Infection of Hp was tested by CLO and histopathology. Base on the history of NSAID consumption, the patients were divided into NSAID users group and non users group.Result:Between 1995 and 1998, 248 patients were studied, they consisted of 95 ulcer patients (50 GU, 40DU, 5 GU+DU) and 163 non ulcer patients. Age ranged from 16‐78 years old. The median age of GU;DU and NU wee 61;49 and 44 yrs respectively. Among 95 ulcer patients, 67.4% were NSAID user and 32.6% were non users, the prevalence of Hp among NSAID users and non users were 20.3% and 81.7% respectively (p<0.01).Among 163 non ulcer patients 36.8% were NSAID users and 63.2% were non users, the prevalence of Hp among NSAID users and non users were 33.1% and 60.2% respectively (p<0.05). Ninety percent of 50 GU patients were NSAID users, the prevalence of Hp among them was 11.1%. The prevalence of Hp among GU patients who didnít use NSAID was 4/5(80%). Among 40 patients with DU,35% were NSAID users and 65% were non users, the prevalence of Hp among users and non users were 42.9% and 92.3% respectively (p<0.01). All patients with GU+DU were NSAID users, 40% of them had Hp positive.Conclusion:The prevalence of Hp among NSAID users was lower than non users. In NSAID users group who had ulcer the prevalence of Hp was lower than those who had non ulcer. This finding support that Hp infection may not increase the risk of ulcer in patient who use NSAID.